- Enrico Colantoni - Keith Mars
- Percy Daggs III - Wallace Fennel
- Francis Capra - Weevil
- Ryan Hansen - Dick Casablancas
- Kyle Gallner - Cassidy Casablancas
- Tessa Thompson - Jackie Cooke
- Tina Majorino - Cindy Mackenzie
- Corinne Bohrer - Lianne Mars
- Erica Gimpel - Alicia Fennel
- Cress Williams - Nathan Woods
- Amanda Seyfried - Lilly Kane
- Kyle Secor - Jake Kane
- Lisa Thornhill - Celeste Kane
- Harry Hamlin - Aaron Echolls
- Lisa Rinna - Lynn Echolls
- Alyson Hannigan - Trina Echolls
- Charisma Carpenter - Kendall Casablancas
- Alona Tal - Meg Manning
- Aaron Ashmore - Troy Vandegraff
- Krysten Ritter - Gia Goodman
- Amanda Toret - Madison Sinclair
- Valorie Curry - Jane Kuhne
- Jonathan Chesner - Corny
- Jessy Schram - Hannah Griffith
- Adam Hendershott - Vincent Clemmons
- Sydney Tamiia Poitier - Mallory Dent
- Paula Marshall - Rebecca James
- Duane Daniels - Van Clemmons
- James Jordan - Lucky
- James Molina - Thumper
- Brad Bufanda - Felix Toombs
- Michael Muhney - Don Lamb
- Max Greenfield - Leo D'Amato
- Daran Norris - Cliff McCormak
- Steve Guttenberg - Woody Goodman
- Ken Marino - Vinnie Vanlowe
- Rodney Rowland - Liam Fitzpatrick
- Rick Peters - Tom Griffith
- Christopher B. Duncan - Clarence Wiedman
- Jeffrey D. Sams - Terrence Cook